منابع مشابه
Mechanism of unidirectional movement of kinesin motors
Kinesin motors have been studied extensively both experimentally and theoretically. However, the microscopic mechanism of the processive movement of kinesin is still an open question. In this paper, we propose a hand-over-hand model for the processivity of kinesin, which is based on chemical, mechanical, and electrical couplings. In the model the processive movement does not need to rely on the...
متن کاملCollective Dynamics of Kinesin-1
Motor proteins are the engines of biology, converting chemical energy to mechanical work in cells. Kinesin-1 is a motor protein that transports vesicles towards the plus end of microtubules, widely believed to be responsible for anterograde transport of synaptic vesicles in neurons. Advances in single-molecule techniques have allowed the characterization of single kinesin motors in vitro at a r...
متن کاملKinesin-1/Hsc70-dependent mechanism of slow axonal transport and its relation to fast axonal transport.
Cytoplasmic protein transport in axons ('slow axonal transport') is essential for neuronal homeostasis, and involves Kinesin-1, the same motor for membranous organelle transport ('fast axonal transport'). However, both molecular mechanisms of slow axonal transport and difference in usage of Kinesin-1 between slow and fast axonal transport have been elusive. Here, we show that slow axonal transp...
متن کاملAlternating-site mechanism of kinesin-1 characterized by single-molecule FRET using fluorescent ATP analogues.
Kinesin-1 motor proteins move along microtubules in repetitive steps of 8 nm at the expense of ATP. To determine nucleotide dwell times during these processive runs, we used a Förster resonance energy transfer method at the single-molecule level that detects nucleotide binding to kinesin motor heads. We show that the fluorescent ATP analog used produces processive motility with kinetic paramete...
متن کاملExperimental and Theoretical Investigation of Mechanism of Kinesin Motility
Kinesin is a motor protein capable of utilizing chemical energy from ATP hydrolysis to generate mechanical force to power its progressive motility along a microtubule track. The mechanism of motility has been a subject of extensive study for last decade. Recently, it has been proposed that novel element-cover strand-is essential in power-stroke-like force generation. In this work we attempt an ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2020
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2020.09.034